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Vitamin K emerging as "life-saving superstar"

Posted in Longevity and Age Management, Aging, Cancer, Cardio-Vascular, Dietary Supplementation, Osteoporosis on Wed February 04, 2009
Numerous studies published in 2008 have shown that vitamin K not only helps regulate calcium balance in the body to ensure calcium remains the bones and away from heart valves and arteries, but it has demonstrated numerous other health benefits. In addition, scientists have been able to develop a form of the nutrient that stays in the body longer than previous forms and is more cost effective to purchase.

Maintaining consistent levels of calcium is essential, especially as we age. Studies have shown that a vitamin K2 deficiency can lead to brittle bones and hardening of the arteries. Conversely, a new study shows that restoring the nutrient can actually reverse the normal aging process of arterial calcification. Another study published in 2008 demonstrated that postmenopausal women in Japan who took both Fosamax® and vitamin K2 for one year had a greater increase in neck bone density than women who only took Fosamax. And an in vitro study published in January 2008 led doctors to conclude that taking a combination of vitamins D3 and K1 can offer a "low-cost strategy for laying down new bone material."

Based on numerous studies, vitamin K2 and vitamin K3 have also been shown to be effective in preventing and treating cancer. German researchers report that in a study of 11,319 men followed for 8.6 years, those who consumed a higher daily intake of vitamin K2 had a 63% reduction in the incidence of advanced prostate cancer. A study published in 2008 demonstrated the ability of vitamin K2 to destroy leukemia cells in vitro. And in patients with viral-induced liver cirrhosis, less than 10% of those patients who took vitamin K2 developed liver cancer, compared to 47% in patients who did not take the supplement. In addition, Apatone®, which combines vitamin C and vitamin K3, showed "promise in delaying biochemical progression in end-stage prostate cancer patients," according to researchers who conducted a study on prostate cancer patients who had not responded to standard therapy and were given high doses of Apatone.

Research conducted by Japanese scientists and published in a 2008 study also shows that vitamin K2 stopped the development of synovial cells, thereby preventing collagen-induced rheumatoid arthritis in a rat model.
News Release: Protection against arterial calcification, bone loss, cancer and aging! LifeExtension www.lef.org January 2009



J Nutr. 2004 Nov;134(11):3100-5.

Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study.

Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC.
Department of Epidemiology & Biostatistics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
Vitamin K-dependent proteins, including matrix Gla-protein, have been shown to inhibit vascular calcification. Activation of these proteins via carboxylation depends on the availability of vitamin K. We examined whether dietary intake of phylloquinone (vitamin K-1) and menaquinone (vitamin K-2) were related to aortic calcification and coronary heart disease (CHD) in the population-based Rotterdam Study. The analysis included 4807 subjects with dietary data and no history of myocardial infarction at baseline (1990-1993) who were followed until January 1, 2000. The risk of incident CHD, all-cause mortality, and aortic atherosclerosis was studied in tertiles of energy-adjusted vitamin K intake after adjustment for age, gender, BMI, smoking, diabetes, education, and dietary factors. The relative risk (RR) of CHD mortality was reduced in the mid and upper tertiles of dietary menaquinone compared to the lower tertile [RR = 0.73 (95% CI: 0.45, 1.17) and 0.43 (0.24, 0.77), respectively]. Intake of menaquinone was also inversely related to all-cause mortality [RR = 0.91 (0.75, 1.09) and 0.74 (0.59, 0.92), respectively] and severe aortic calcification [odds ratio of 0.71 (0.50, 1.00) and 0.48 (0.32, 0.71), respectively]. Phylloquinone intake was not related to any of the outcomes. These findings suggest that an adequate intake of menaquinone could be important for CHD prevention.




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